Trisomy 11 in myelodysplastic syndrome-derived acute myeloblasts leukaemias
- 24 April 2009
- journal article
- research article
- Published by Wiley in European Journal of Haematology
- Vol. 43 (2) , 173-177
- https://doi.org/10.1111/j.1600-0609.1989.tb00274.x
Abstract
Here we report 3 cases of trisomy 11 observed in 1 patient with secondary acute myeloblastic leukaemia and in 2 patients with spontaneous acute myeloblastic leukaemia. In all 3 patients, the picture of overt leukaemia arose following a clinically established myelodysplastic syndrome. These findings, together with the previously reported occurrence of trisomy 11 in myelodysplastic syndrome and in acute myeloblastic leukaemia, suggest that this abnormality can be considered specifically associated with myelodysplastic syndrome and with the subsequent and related acute myeloblastic leukaemia.Keywords
This publication has 19 references indexed in Scilit:
- Trisomy 11 in chronic myelomonocytic leukemia: Report of two cases and review of the literatureCancer Genetics and Cytogenetics, 1988
- Trisomy 11 in myelodysplasiaCancer Genetics and Cytogenetics, 1988
- Cytogenetic characteristics of therapy‐related acute nonlymphocytic leukaemia, preleukaemia and acute myeloproliferative syndrome: correlation with clinical data for 61 consecutive casesBritish Journal of Haematology, 1987
- Refined chromosome analysis as an independent prognostic indicator in de novo myelodysplastic syndromesBlood, 1986
- Prognostic implications of morphology and karyotype in primary myelodysplastic syndromesBlood, 1986
- Clinical and cytogenetic correlations in 63 patients with therapy-related myelodysplastic syndromes and acute nonlymphocytic leukemia: further evidence for characteristic abnormalities of chromosomes no. 5 and 7.Journal of Clinical Oncology, 1986
- Prognostic factors in the myelodysplastic syndromes: importance of initial data on peripheral blood counts, bone marrow cytology, trephine biopsy and chromosomal analysisBritish Journal of Haematology, 1985
- Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor.Proceedings of the National Academy of Sciences, 1985
- Trisomy 11 in preleukemiaCancer Genetics and Cytogenetics, 1985
- Cytogenetic follow-up of patients with nonlymphocytic leukemia. II. Acute nonlymphocytic leukemiaCancer Genetics and Cytogenetics, 1981