The Application of Multicompartmental Analysis to Problems of Clinical Medicine

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Abstract
This combined Clinical Staff Conference presents the mathematical basis and the investigational techniques and tools of comparemental analysis in the study of Ca, bilirubin and im-munoglobulin metabolism, with examples of studies in disease states and discussions of limitations. The dynamics of bilirubin metabolism are illustrated with data from normals and from patients with Gilbert''s disease, Dubin-Johnson syndrome and cirrhosis. Calcium metabolism and its hormonal regulation are discussed in the light of studies in normals and hypoparathyroid patients. Data from normals and patients with disorders of immunoglobulin cata-bolism (myotonic dystrophy, ataxia telangiectasia, etc., loss (for example, intestinal lymphangiectasia), and decreased immunoglobulin synthesis illustrate analysis of immunoglobulin metabolism.