CELL TRANSFORMATION BY DIFFERENT FORMS OF POLYOMA VIRUS DNA
- 1 July 1964
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 52 (1) , 148-152
- https://doi.org/10.1073/pnas.52.1.148
Abstract
The transforming ability of DNA extracted from polyoma virus is not the exclusise property of any one of the various molecular species of the DNA. Molecules both in the ring form and in the open form are able to transform. Whether molecules of component III produce transformation cannot be established as yet. These results with hamster cells show that a special type of polyoma DNA molecule is not required from the start in order to obtain transformation. They do not exclude the possibility that a special type is required at some later stage. The implication is therefore that the initial stages are similar in the two types of virus -cell interaction which lead either to transformation or to plaque formation.Keywords
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