Inhibition of Development of Chick Embryo Liver by Aminoguanidine

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Abstract
Aminoguanidine sulfate (AGS) when injected into the yolk of a 4-day embryonated egg produced a severe inhibition of liver development of the chick embryo when the specimens were examined 10 days later. Other organs and tissues of the specimens appeared to be relatively unaffected. Livers were more susceptible to AGS administration at 2-4 days'' incubation, and studies on the progressive effects of the compound indicated cord formation was retarded within 96 hours after injection. In the livers of a typical treated 14-day embryo, the parenchymal cells apparently were the sites of inhibition as the surviving tissue was composed largely of connective tissue and cystic structures. The most effective sub-lethal dose at 4 days incubation was ineffective when given at 9-10 days'' incubation.

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