THE EFFECT OF CORTISOL AND CERTAIN SYNTHETIC STEROIDS ON THE PERMEABILITY OF SYNOVIAL MEMBRANE IN THE RABBIT

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Abstract
SUMMARY: 1. An investigation of the effects of cortisol and certain synthetic steroids on the permeability of synovial membrane has been carried out by studying the rate of absorption of phenolsulphonphthalein from the talocrural joints of rabbits. 2. Cortisol, betamethasone, dexamethasone and prednisolone all decreased the permeability of synovial membrane to approximately the same extent. Fluorohydrocortisone had no detectable effect. 3. The implications of these observations with regard to structure-activity relationships, physiological significance and mechanism of action are discussed.