Synthesis and Antiviral Activity of Novel Aza-acyclonucleosides
- 1 February 1999
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 18 (2) , 227-238
- https://doi.org/10.1080/15257779908043070
Abstract
We have prepared a series of novel aza-acyclonucleosides as potential antiviral agents. These compounds were prepared from diethanolamine and the desired purine or pyrimidine base via a Mitsunobu coupling. No antiviral activity was observed against either HSV-1 or HCMV.Keywords
This publication has 13 references indexed in Scilit:
- Synthesis of oligo(5-aminopentanoic acid)-nucleobases (APN): potential antisense agentsBioorganic & Medicinal Chemistry Letters, 1997
- Synthesis of 2‘-Aminomethyl Derivatives of N-(2-(Phosphonomethoxy)ethyl) Nucleotide Analogues as Potential Antiviral AgentsJournal of Medicinal Chemistry, 1996
- Application of the Mitsunobu-Type Condensation Reaction to the Synthesis of Phosphonate Derivatives of Cyclohexenyl and Cyclohexanyl NucleosidesThe Journal of Organic Chemistry, 1995
- Novel Acyclic Nucleotides and Nucleoside 5'-Triphosphates Imitating 2',3'-Dideoxy-2',3'-didehydro nucleotides: Synthesis and Biological PropertiesJournal of Medicinal Chemistry, 1994
- 2-Hydroxyethoxyethylated Bases as Acyclic Analogues of 1,5-Anhydrohexitol Nucleoside DerivativesNucleosides and Nucleotides, 1994
- Selective Removal of an N-BOC Protecting Group in the Presence of a tert-Butyl Ester and Other Acid-Sensitive GroupsThe Journal of Organic Chemistry, 1994
- Novel acyclonucleotides: synthesis and antiviral activity of alkenylphosphonic acid derivatives of purines and a pyrimidineJournal of Medicinal Chemistry, 1993
- The benzoylation of uracil and thymineTetrahedron Letters, 1984
- Rapid chromatographic technique for preparative separations with moderate resolutionThe Journal of Organic Chemistry, 1978
- 9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes groupNature, 1978