Role of glial amino acid transporters in synaptic transmission and brain energetics
- 8 July 2004
- Vol. 47 (3) , 217-225
- https://doi.org/10.1002/glia.20027
Abstract
This article reviews how the uptake of neurotransmitter by glial amino acid transporters limits the spatial spread of transmitter to preserve the independent operation of nearby synapses, temporally shapes postsynaptic currents, and regulates the effects of tonic transmitter release. We demonstrate the importance of amino acid uptake and recycling mechanisms for preventing the loss of energetically costly neurotransmitter from the brain, and also examine the suggestion that glutamate uptake into glia plays a key role in regulating the energy production of the brain. Finally, we assess the role of glial amino acid transporters in transmitter recycling pathways.Keywords
This publication has 93 references indexed in Scilit:
- Cooperation between independent hippocampal synapses is controlled by glutamate uptakeNature Neuroscience, 2002
- Regulation of the glutamine transporter SN1 by extracellular pH and intracellular sodium ionsThe Journal of Physiology, 2002
- NMR spectroscopic study on the metabolic fate of [3-13C]alanine in astrocytes, neurons, and cocultures: Implications for glia-neuron interactions in neurotransmitter metabolismGlia, 2000
- Extrasynaptic Glutamate Spillover in the Hippocampus: Dependence on Temperature and the Role of Active Glutamate UptakeNeuron, 1997
- LTP of AMPA and NMDA Receptor–Mediated Signals: Evidence for Presynaptic Expression and Extrasynaptic Glutamate Spill-OverNeuron, 1996
- Glutamine from Glial Cells Is Essential for the Maintenance of the Nerve Terminal Pool of Glutamate: Immunogold Evidence from Hippocampal Slice CulturesJournal of Neurochemistry, 1995
- Glial contributions to excitatory neurotransmission in cultured hippocampal cellsNature, 1994
- Glutamate uptake from the synaptic cleft does not shape the decay of the non-NMDA component of the synaptic currentNeuron, 1993
- Uptake, release and metabolism of alaume in neurons and astrocytes in primary culturesJournal of Neuroscience Research, 1993
- Histochemistry of glutamate metabolizing enzymes in the rat cerebellar cortexNeuroscience Letters, 1991