Chloroquine inhibits the production of a mononuclear cell factor by inhibition of lectin binding
Open Access
- 1 August 1984
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 27 (8) , 888-896
- https://doi.org/10.1002/art.1780270808
Abstract
The effect of chloroquine (CQ) on the ability of normal human peripheral blood monocytes to produce a soluble mononuclear cell factor (MCF) capable of stimulating prostaglandins from adherent rheumatoid synovial cells was studied. CQ inhibited concanavalin A (Con A)‐ and bacterial peptidoglycan‐induced MCF activity, but not colchicine‐induced activity, in a dose‐dependent manner. After incubation with CQ for 20 minutes, 3H Con A binding was reduced by 50%, and metabolism of pre‐bound 3H Con A was inhibited. These data suggest that CQ can inhibit MCF production by inhibition of lectin binding, perhaps by inhibition of receptor recycling.This publication has 30 references indexed in Scilit:
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