EFFECTS OF GRADED PRESSURES ON THE TAIL OF THE MOUSE

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Abstract
Uniform pressure was applied over the lenght of the tail of the mouse by a pneumatic sheath. 30 mm. Hg pressure was well tolerated for a week. Higher pressures within the inf rasys-tolic range caused progressively more necrosis of the distal end. The subsequent survival of the tail corresponded with the removal of fluorescein from the skin both during and after the application of pressure. The systolic pressure was estimated by a tail-cuff method in which fluorescein was used to demonstrate blood flow past the cuff.