Comparative studies on the fermentative production of lantibiotics by staphylococci
- 1 February 1990
- journal article
- research article
- Published by Springer Nature in Applied Microbiology and Biotechnology
- Vol. 32 (5) , 511-517
- https://doi.org/10.1007/bf00173719
Abstract
Summary The production of the lanthionine-containing polypeptide antibiotics gallidermin from Staphylococcus gallinarum TÜ 3928 and pep 5 from S. epidermidis 5 is investigated with respect to regulation and stimulation of productivity by media components, optimization of both the media used and the fermentation process and is compared to the production of the lantibiotic epidermin from S. epidermidis TÜ 3298. Efficient methods for rapid quantification of lantibiotics, optimization of the media and a primary enrichment by adsorption chromatography are reported.Keywords
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