Plasma Clearance of57Cobalt-Labelled Vitamin B12Bound in Vitro and in Vivo to Transcobalamin I and II
- 1 January 1969
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Clinical and Laboratory Investigation
- Vol. 23 (3) , 201-211
- https://doi.org/10.3109/00365516909077650
Abstract
Radioactive-labelled B12 bound to transcobalamin I has an initial distribution volume twice the plasma volume, a fractional turnover rate of 45 to 60 per cent per day, a biologic half-life in plasma of 6 days and an extra-vascular distribution of 74 to 81 per cent. Transcobalamin II had a fractional turnover rate of 1536 and 1944 per cent per day, a biologic half-life of 12 hours and an extravascular distribution of 90 per cent.Keywords
This publication has 19 references indexed in Scilit:
- Nature of the relationship between vitamin B12 binding and cell uptakeArchives of Biochemistry and Biophysics, 1967
- Function of Transcobalamin II: A B12 Binding Protein in Human Plasma.Experimental Biology and Medicine, 1966
- Vitamin B12 Kinetics in Man. Implications on total-body-B12-determinations, human requirements, and normal and pathological cellular B12 uptakePhysics in Medicine & Biology, 1966
- The Binding of Vitamin B12 Added in Vitro and in Vivo to Normal Human Serum Proteins Separated on Ion Exchange CelluloseScandinavian Journal of Haematology, 1965
- Abnormal Transport of Vitamin B12 in Plasma in Chronic Myelogenous LeukæmiaNature, 1964
- Long-Term Excretion of Co57-Vitamin B12 and Turnover Within the PlasmaThe American Journal of Clinical Nutrition, 1964
- THE PLASMA DISAPPEARANCE OF INTRAVENOUSLY ADMINISTERED COBALT58 VITAMIN B12*Journal of Clinical Investigation, 1960
- The amount of circulating albumin in normal humansScandinavian Journal of Clinical and Laboratory Investigation, 1959
- Sur une nouvelle méthode de dosage du cholestérol. lié aux α et aux β-lipoprotéines du sérumClinica Chimica Acta; International Journal of Clinical Chemistry, 1958
- THE IN VITRO BINDING OF COBALT60 LABELED VITAMIN B1 BY NORMAL AND LEUKEMIC SERAJournal of Clinical Investigation, 1958