Cyclic Biological Expression in Mouse Mammary Tumors
- 2 April 1982
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 216 (4541) , 68-70
- https://doi.org/10.1126/science.7063874
Abstract
Biological characteristics were assessed in GR mouse mammary tumors during 22 serial transplantations. Although unidirectional progression from hormone dependency to independency was observed, other biological markers such as progesterone receptors, polyploid frequency and thymidine kinase activity demonstrated cyclic phenomena every fourth to sixth transplant generation, suggesting the continued presence of regulatory mechanisms among various cells subpopulations.This publication has 13 references indexed in Scilit:
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