Festphasensynthese von O‐Glycopeptiden

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Abstract
Solid Phase Synthesis of O‐GlycopeptidesThe solid phase synthesis of a number of O‐glycopeptides are described. A polystyrene resin containing p‐alkoxybenzyl alcohol groups was used as support. Glycosylamino acids of 2‐acetamido‐2‐deoxy‐D‐galactose and threonin or serin can be coupled with further amino acids and also with other glycosylated amino acids. The introduction of disaccharide‐containing amino acids gives uncomplete reaction. The final cleavage from the carrier and the deprotection present no difficulties. Partial structures of the ovine submaxillary mucin and of human and porcine glycophorin are prepared.

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