Disappearance Rate of133Xenon, 4-Iodoantipyrine-131I and131I-from Human Skeletal Muscles and Adipose Tissue

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Abstract
Lindbjerg, I. F. Disappearance Rate of 133Xenon, 4-Iodo-antipyrine-131I and 131I-from Human Skeletal Muscles and Adipose Tissue. Scand. J. clin. Lab. Invest. 19, 120-128, 1967. A comparison of the disappearance of 133Xe and 131I-tagged 4-iodo-antipyrine (131I-AP), simultaneously injected in human leg muscles, was performed at rest and during hyperaemia, produced by maximal muscular exercise during ischaemia. At rest the ratio between 133Xe and 131I-antipyrine removal rates in 16 legs of subjects133Xe and 131I-increased from 0.94 at rest to 1.98 during hyperaemia, indicating a relatively slower removal of 131I-at higher blood-flows. In subcutaneous adipose tissue the 133Xe/131I-AP-removal ratio was 0.102 (S. D. 0.050). The findings are compatible with maintenance of diffusion equilibrium between tissue and blood in respect to the lipid-soluble indicators 133Xe and 131I-Ap, while the removal of free 131I-seems to be impeded at high blood-flows. Variation of the Xe/I-AP removal ratio in muscle is probably mainly caused by varying fat content.