LYMPHOCYTE-PROLIFERATION INHIBITORY FACTOR (PIF) IN ALCOHOLIC LIVER-DISEASE
- 1 January 1976
- journal article
- research article
- Vol. 26 (1) , 42-45
Abstract
Lymphocyte proliferation inhibitory factor (PIF) was determined in the supernatants of PHA[phytohemagglutinin]-stimulated lymphocytes from patients with alcoholic liver disease. PIF was assayed by determining inhibition of DNA synthesis in WI-38 human lung fibroblasts. A 2-fold greater inhibition in thymidine incorporation into DNA by lung fibroblasts was observed in supernatants of PHA stimulated lymphocytes from patients with alcoholic hepatitis or active Laennec''s cirrhosis as compared with that found in control subjects or patients with fatty liver. Decreased liver cell regeneration seen in some patients with alcoholic hepatitis may be due to increased elaboration of PIF.This publication has 11 references indexed in Scilit:
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