Clofibrate and Atherosclerosis

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Abstract
Despite a variety of efforts aimed at altering its course, atherosclerosis and its sequelae are still major causes of death in the United States and other industrialized nations. In the absence of a single, clearcut etiologic agent, therapeutic interventions have focused on the known multiple risk factors for atherosclerosis, including hypercholesterolemia, hypertension, smoking and diabetes mellitus, If atherosclerosis were an acute disease, easily detected and followed, with a clear-cut outcome in a short time, it would be relatively simple to evaluate the effects of interventions designed to alter its progression. It is, on the contrary, a chronic, relapsing and remitting . . .