Chiral Resolution of Dipeptides by Ligand Exchange Chromatography on Chemically Bonded Chiral Phases
- 1 October 1996
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography & Related Technologies
- Vol. 19 (17-18) , 2933-2942
- https://doi.org/10.1080/10826079608015118
Abstract
This paper deals with studies on the optical resolution of glycyl-DL-amino acid dipeptides and diastereomeric dipeptides on three different chemically bonded chiral ligand exchange chromatography (LEC)-phases. The phases were prepared by binding L-proline or L-hydroxyproline to silica gel using different silanes as spacer. Using 10−5 M copper(H) sulface as a mobile phase, eleven glycyl-dipeptides were resolved, nearly all of them with baseline separations. Several dipeptides containing two stereogenic centres were at least partially resolved into the four stereoisomers.Keywords
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