THE ROLE OF β1 ‐ AND β2‐ADRENOCEPTORS IN THE INHIBITION OF GASTRIC ACID SECRETION IN THE DOG

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Abstract
1 Characterization of the β-adrenoceptors mediating inhibition of gastric acid secretion in the conscious Heidenhain pouch dog has been investigated by determination of the effects of propranolol, (+)-propranolol, practolol and H 35/25 on salbutamol and isoprenaline-induced inhibition of gastric acid secretion. 2 The gastric antisecretory effect of salbutamol was significantly blocked by propranolol and H35/25 but not by practolol or (+)-propranolol. The effect of isoprenaline was significantly blocked by propranolol and practolol but not by H35/25 or (+)-propranolol. 3 It is concluded that both β1- and β2-adrenoceptors can mediate inhibition of pentagastrin-induced gastric secretion in conscious dogs with a Heidenhain pouch. Salbutamol exerts its antisecretory effect through β2-adrenoceptors, whereas isoprenaline mediates its effects primarily through β1-adrenoceptors. 4 The results are discussed with regard to the sub-classification of β-adrenoceptors and to the possible role of adrenoceptors in the physiological control of gastric secretion. 5 In this study it is concluded that the tachycardia induced by isoprenaline or salbutamol is mediated primarily through reflexes activated by β2-adrenoceptor mediated vasodilatation.