ROLE OF SECRETIN ON POSTPRANDIAL GASTRIN-RELEASE IN THE DOG - A FURTHER STUDY

  • 1 January 1981
    • journal article
    • research article
    • Vol. 90  (3) , 504-508
Abstract
To determine the physiologic role of secretin on gastric secretory function, the effects of secretin in a physiologic dose on gastrin release and gastric acid secretion were studied in 4 dogs with vagally innervated fundic pouches. Three sets of experiments were performed in each dog: meal alone, meal after i.v. cimetidine to suppress acid secretion and release of secretin, and meal after i.v. cimetidine with simultaneous i.v. secretin, 0.03 clinical unit (CU)/kg-h. A significant increase in plasma secretin concentration occurred after ingestion of a meal. The postprandial increase in the secretin level was abolished by i.v. cimetidine 200 mg, whereas i.v. cimetidine resulted in a marked increase in the postprandial plasma gastrin concentration significantly greater than that after a meal alone. A plasma secretin level comparable to that of the postprandial period could be achieved in the same fasting dogs by i.v. secretin, 0.03 CU/kg-h in 2% dog albumin solution. The postprandial plasma gastrin concentration and acid secretion following i.v. cimetidine were significantly decreased by simultaneous i.v. secretin at a dose of 0.03 CU/kg-h. Secretin seems to play a significant role in the regulation of release of gastrin and gastric secretion of acid in the postprandial state in dogs.