Secretin is an enterogastrone in the dog

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Abstract
To determine the physiological significance of secretin on gastric secretion, effects of normal rabbit serum (control) and rabbit antisecretin serum (anti-S) on meat meal-stimulated gastric secretion of acid and pepsin from vagally innervated fundic pouches were studied in 4 dogs with gastric fistulas. The i.v. administration of control serum did not affect the postprandial rise in plasma secretin concentration, whereas i.v. anti-S virtually eliminated the circulating plasma secretin. Both plasma gastrin concentration and acid output following i.v. anti-S were significantly greater than those following i.v. control serum. Pepsin outputs in the 2 groups of experiments were not significantly different. In the same dogs in the fasting state, during i.v. infusion of secretin in doses of 0.06 and 0.125 U.cntdot.kg-1.cntdot.h-1, the acid output stimulated by i.v. human synthetic gastrin in a dose of 0.25 .mu.g.cntdot.kg-1.cntdot.h-1 was significantly less than that during i.v. saline. Evidently secretin in a physiological dose can inhibit postprandial release of gastrin and gastric secretion of acid, and thus secretin is an enterogastrone in the dog.