The metabolism ofo-fluoroaniline by rats, rabbits and marmosets
- 1 January 1986
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 16 (6) , 555-566
- https://doi.org/10.3109/00498258609043544
Abstract
1. o-Fluroaniline is rapidly metabolized and excreted in rats, rabbits and marmosets. Following a single oral dose of 14C-fluoroaniline of about 20 mg/kg, more than 80% of the dose is excreted in 0–24 h, the urine being the major route of excretion for all three species. 2. For all three species, 4-amino-3-fluorophenol is a major metabolite, conjugated at oxygen with either sulphate or glucuronic acid. 4-Acetylamino-3-fluorophenyl sulphate or glucuronide are also significant metabolites. 3. An h.p.l.c. method with electrochemical detection was developed for monitoring exposure of plant workers to o-fluoroaniline, based on 4-amino-3-fluorophenyl sulphate.This publication has 6 references indexed in Scilit:
- 2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methaemoglobin and urine analysesInternationales Archiv für Arbeitsmedizin, 1984
- The fate of 4-cyano-N, N-dimethylaniline in rats; a novel involvement of glutathione in the metabolism of anilinesXenobiotica, 1984
- The metabolism of 3-chloro-4-fluoro-aniline in dog and ratXenobiotica, 1980
- The fate of phenylhydroxylamine in human red cellsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1976
- Metabolic N-oxidation of secondary and primary aromatic amines as a route to ring hydroxylation, to various N-oxygenated products, and to dealkylation of secondary aminesBiochemical Pharmacology, 1976