Antagonist Studies: Comparison of Desoxypyridoxine and Pyridoxine-Deficiency Therapy on Various Vitamin B6 Enzymes.

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Abstract
Mice receiving a vit. B6 deficient-high protein diet were observed to have significantly lower transaminase, dopa decarboxylase and cysteine desulfhydrase activities as compared to similar animals receiving an identical diet supplemented with pyridoxine. Cysteine desulfhydrase was the most sensitive to vit. B6 deprivation, followed by transaminase and dopa decarboxylase. Admn. of desoxypyridoxine to mice receiving an ad libitum stock diet containing adequate vit. B6 significantly decreased transaminase and dopa decarboxylase activity. However, cysteine desulfhydrase activity was uninhibited. A possible explanation of the observed results is discussed, the potentialities of vit. antagonists as precise chemotherapeutic agents being indicated.