Mode of Action of Desoxypyridoxine
- 1 February 1949
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 70 (2) , 293-299
- https://doi.org/10.3181/00379727-70-16904
Abstract
Using tyrosine decarboxylase it was demonstrated that desoxypyridoxine, an antimetabolite for the vit. B6 group, exerts its inhibitory effect by being first converted into desoxypyridoxine phosphate. This compound competes with pyridoxal phosphate for the apoenzyme but has little or no effect once the latter has combined with the apoenzyme.Keywords
This publication has 7 references indexed in Scilit:
- INHIBITION OF THE ACTION OF TYROSINE DECARBOXYLASE BY PHOSPHORYLATED DESOXYPYRIDOXINEJournal of Biological Chemistry, 1947
- THE EFFECT OF PYRIDOXINE ANALOGUES ON TRYPTOPHANE METABOLISM IN THE RATJournal of Biological Chemistry, 1947
- Antipyridoxine Activity of 2, 4-Dimethyl-3-Hydroxy-5-Hydroxymethylpyridine in the ChickExperimental Biology and Medicine, 1946
- SOME PROPERTIES OF SYNTHETIC CODECARBOXYLASEJournal of Biological Chemistry, 1945
- THE FUNCTION OF PYRIDOXINE: CONVERSION OF MEMBERS OF THE VITAMIN B6 GROUP INTO CODECARBOXYLASEJournal of Biological Chemistry, 1945
- TRANSAMINASES1945
- Experiments on Bacteria in relation to the Mechanism of Enzyme ActionBiochemical Journal, 1927