Measurement of Trazodone Using Solid-Phase Extraction and Wide-Bore Capillary Gas Chromatography with Nitrogen-Selective Detection
- 31 December 1987
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 12 (3) , 150-152
- https://doi.org/10.1093/jat/12.3.150
Abstract
A method for the determination of the antidepressant drug trazodone is presented. 8-Hydroxyloxapine is used as the Internal standard. A simple solid-phase extraction procedure utilizing disposable reversed-phase C19 columns is described. Samples are analyzed by go chromatography with nitrogen-selective detection using a wide-bore capillary column with a permanently bonded, nonpolar stationary phase. The assay possesses linearity to 3.0 µg/mL, sensitivity to at least 0.25 µg/mL, recovery averaging 96%, and between-run precision reflected by a CV of 5.6%. We conclude that the method reported here is ideally suited for monitoring therapeutic and toxic levels of trazodone.This publication has 5 references indexed in Scilit:
- Measurement of Antidepressants Using Solid-Phase Extraction and Wide-Bore Capillary Gas Chromatography with Nitrogen-Selective DetectionTherapeutic Drug Monitoring, 1988
- The Capillary Gas Chromatographic Determination of Trazodone in Biological SpecimensJournal of Analytical Toxicology, 1984
- Plasma Levels of Trazodone: Methodology and ApplicationsPharmacology, 1984
- Advances in fused-silica column technology for the analysis of underivatized drugsJournal of Chromatography A, 1983
- Application of fused-silica capillary gas chromatography to the analysis of underivatized drugsJournal of Chromatography A, 1982