Metabolism of Bovine Semen. VIII. Fluoroacetate as an Inhibitor of Spermatozoan Motility, Glycolysis, and Respiration

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Abstract
Sodium fluoroacetate in concentrations as high as 0.01[image] was tested as an inhibitor of the motility, glycolysis and respiration of bovine spermatozoa in heated skimmilk, egg yolk-citrate (1:3), and modified Ringer solution. Effective inhibition of motility and glycolysis was not obtained. Endogenous respiration was 70% inhibited by 0.01[image] fluoroacetate; respiration with substrates of 0.01[image] acetate, glucose and fructose was inhibited 70 to 90%. Production of C14O2 from acetate-1-C14 was almost completely blocked by fluoroacetate.