[Gd-AAZTA]-: A New Structural Entry for an Improved Generation of MRI Contrast Agents
- 29 October 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Inorganic Chemistry
- Vol. 43 (24) , 7588-7590
- https://doi.org/10.1021/ic0489692
Abstract
An innovative MRI contrast agent based on the unprecedented and easily obtained ligand AAZTA is described. The simple and straightforward synthesis of the ligand, together with the potentiometric and relaxometric behavior of the corresponding Gd(III) chelate, is reported. The complex [Gd(AAZTA)]- shows outstanding magnetic properties connected with high thermodynamic stability in aqueous solution and a nearly complete inertness toward the influence of bidentate endogenous anions, placing this compound as one of the most promising candidates for the development of high performance MRI contrast agents.Keywords
This publication has 10 references indexed in Scilit:
- A Tris-hydroxymethyl-Substituted Derivative of Gd-TREN-Me-3,2-HOPO: An MRI Relaxation Agent with Improved EfficiencyJournal of the American Chemical Society, 2000
- [GdPCP2A(H2O)2]-: A Paramagnetic Contrast Agent Designed for Improved Applications in Magnetic Resonance ImagingJournal of Medicinal Chemistry, 2000
- Ternary Gd(III)L-HSA adducts: evidence for the replacement of inner-sphere water molecules by coordinating groups of the protein. Implications for the design of contrast agents for MRIJBIC Journal of Biological Inorganic Chemistry, 2000
- Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and ApplicationsChemical Reviews, 1999
- Lanthanide(III) chelates for NMR biomedical applicationsChemical Society Reviews, 1998
- Stability constants and 1H relaxation effects of ternary complexes formed between gd‐dtpa, gd‐dtpa‐bma, gd‐dota, and gd‐edta and citrate, phosphate, and carbonate ionsMagnetic Resonance in Medicine, 1997
- Structural and Dynamic Parameters Obtained from 17O NMR, EPR, and NMRD Studies of Monomeric and Dimeric Gd3+ Complexes of Interest in Magnetic Resonance Imaging: An Integrated and Theoretically Self-Consistent Approach1Journal of the American Chemical Society, 1996
- Determination of the number of inner-sphere water molecules in lanthanide(III) polyaminocarboxylate complexesJ. Chem. Soc., Dalton Trans., 1992
- Field-cycling relaxometry of protein solutions and tissue: Implications for MRIProgress in Nuclear Magnetic Resonance Spectroscopy, 1990
- NMR-Relaxation Mechanisms of O17 in Aqueous Solutions of Paramagnetic Cations and the Lifetime of Water Molecules in the First Coordination SphereThe Journal of Chemical Physics, 1962