Synthetic studies relevant to biosynthetic research on vitamin B12. Part 8. Synthesis of (±)-Faktor-I octamethyl ester
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 6,p. 1577-1586
- https://doi.org/10.1039/p19880001577
Abstract
Several variations have been explored of the general synthesis of chlorins which uses a photochemical ring-closure of the macrocycle as the key step. This work leads to a synthesis of (±)-Faktor-I octamethyl ester, a chlorin which arises, in the free-acid form, by aromatisation of the mono-C-methylated intermediate on the biosynthetic pathway to vitamin B12. This synthesis confirms the structure of Faktor-I and allows labelled samples to be prepared.This publication has 5 references indexed in Scilit:
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