Tst-1, a member of the POU domain gene family, binds the promoter of the gene encoding the cell surface adhesion molecule P0.
Open Access
- 1 March 1991
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 11 (3) , 1739-1744
- https://doi.org/10.1128/mcb.11.3.1739
Abstract
Tst-1, a member of the POU domain gene family, is expressed in specific neurons and in myelinating glia in the mammalian nervous system. Bacterially expressed Tst-1 binds specifically to the promoter of the gene encoding myelin protein P0, a Schwann cell surface adhesion molecule. In cotransfection assays, Tst-1 can specifically repress the P0 promoter. The N-terminal part of Tst-1 protein is highly glycine- and alanine-rich, a structural feature shared by the helix-loop-helix protein TFEB.Keywords
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