Separation of Xanthine Derivates by High Pressure Liquid Chromatography and Application to Plasma Analysis
- 1 January 1980
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 3 (10) , 1537-1547
- https://doi.org/10.1080/01483918008062794
Abstract
High pressure liquid chromatography (HPLC) methods were developed for separation and plasma analysis of ten xanthine derivates. Separation was evaluated on silica column and on three different reverse phase columns, with optimum conditions obtained on C6 spherisorb column using isocratic elution with phosphate buffer 10−2 M, pH 2.7 - acetonitrile mixture (80/20 V/V). Determination of these xanthine derivates in plasma for therapeutic control was studied.Keywords
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