Toward Synthetic Transcription Activators: Recruitment of Transcription Factors to DNA by a PNA-Peptide Chimera
- 6 February 2002
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 124 (9) , 1838-1839
- https://doi.org/10.1021/ja0164226
Abstract
A PNA-peptide chimera designed to mimic the biochemical function of transcription activators has been synthesized and characterized. The bis-PNA segment binds specifically to a DNA site while the 20-residue peptide is capable of binding to the transcription factors Gal11 and Gal80. The PNA-peptide chimera thus mimics one of the central functions of a native transcription activator, recruitment of transcription factors to a specific DNA site.Keywords
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