Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences.

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Abstract
An eel calmodulin c[complementary]DNA probe was used to isolate a calmodulin gene from a chicken DNA library. Sequence analysis revealed this calmodulin gene (cCM1) to contain the nucleotides that code for 148 amino acids, a termination codon and 486 residues of 3''-noncoding sequence before an A-A-T-A-A-A poly(A) addition signal. The amino acid sequence derived from these nucleotides is 87% homologous to that of bovine brain calmodulin. cCM1 is 1 of 2 calmodulin genes in the chicken genome but is unique in that it does not contain intervening sequences to interrupt the structural segments of the protein. cCM1 probably originated as a processed gene copy derived from the other calmodulin gene, cCL1, a circumstance usually associated with pseudogenes. cCM1 appears to be a functional member of a multigene family whose expression is specific for muscle cells.