Semisynthesis of Kopsidine a and B via a Polonovski-Potier Reaction
- 1 December 1993
- journal article
- research article
- Published by Taylor & Francis in Natural Product Letters
- Vol. 3 (4) , 291-298
- https://doi.org/10.1080/10575639308043879
Abstract
Kopsidine A 4a and B 4b were synthesised from kopsingine N-oxide via a biomimetic Polonovski-Potier reaction. 1,4-Addition of CH3OH or C2H5OH on the intermediate iminium salts, followed by 1,2-addition of the C-17 hydroxyl function produced the expected alkaloids.Keywords
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