Effects of traditional medicines, Gosya‐jinki‐gan, “Kyushin” and “Reiousan” on sexual and learning behaviour in chronically stressed mice

Publisher Website
Google Scholar
Abstract
Traditional medicines, such as Gosya‐jinki‐gan (Niu‐Che‐Shen‐Qi‐Wan) extract preparation (KJE), “Kyushin” (KY–2) and “Reiousan” (R–03) were studied to determine their effects on sexual and learning behaviour in mice subjected to chronic “hanging stress”. Drugs were given orally once a day for 14 days, and sexual (licking, mounting and intromission) and learning (memory retrieval and memory extinction) behaviour were observed. KJE and R–03 protected mice against the stress‐induced decrease of licking, mounting and intromission behaviour, and increases of acceleration of memory loss and failure of memory retrieval. KY–2 protected mice against stress‐induced decrease of licking and intromission behaviour, and increases of acceleration of memory loss and failure to retrieve memory. These results suggest that these drugs have protective effects against chronically exhausted states.