INVESTIGATIONS OF THE URINARY EXCRETION PATTERN IN PSYCHOTIC PATIENTS

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Abstract
Chromatographic analysis of urines of 21 psychotic patients for urinary indoles revealed the presence of an unknown compound, in the majority of schizophrenic urines which was absent from the majority of urines of non-schizophrenic mental patients. The urines of psychotics showed no significant abnormalities on chromatographic analysis for amino acids and in the "Fluorindal reaction". A modification of the standard gly-oxylic acid test is described. The results of the test with urines of 128 psychotic patients are evaluated. It is concluded that the modified test confirmed results previously obtained in the positive range, increased the number of negative tests with schizophrenics and added to the sensitivity of the test. It also improved the clarity of the test colors. The effect of treatment of urines with H2O2 on the glyoxylic acid test was studied and it was found that the oxidizer eliminates the interference of non-indolic substances with the test. The effect of some organic non-psychotic disorders on the test results is noted and the implication discussed.

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