AGE AND SEX DIFFERENCES IN HORMONE CONTENT OF THE RABBIT HYPOPHYSIS

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Abstract
Age and sex differences in hormone content of the rabbit hypophysis were studied by means of implantation into immature [female] guinea pigs. The [male] pituitary produced greater follicle stimulation and luteinization than the [female], and also greater stimulation of the adrenal cortex. Thyrotropic effects were equal. Pituitaries from 10-day-old rabbits produced thyroid and adrenal stimulation but no gonadotropic effects. At 15 and 21 days follicle stimulation was produced. Glands from 28-day and older rabbits produced both follicle stimulation and luteinization of a moderate degree. Thyrotropic effects were greater from pituitary tissue from immature rabbits. Glands from old [female] rabbits produced about the same degree of follicle stimulation and luteinization as young mature [female][female]; there was less thyroid stimulation and greater adrenal cortex stimulation.