THE EFFECT OF 17-HYDROXY-11-DEHYDROCORTICOSTERONE ON THE GROWTH OF YOUNG ADRENALECTOMIZED RATS

Abstract
The effect of 17-hydroxy-11-dehydrocorti-costerone, at daily dosage levels of 0.05-1.0 mg., on the survival and growth of 4-wks.-old adrenalectomized rats was detd. The compound at doses of 1/8 to one mg. is capable of maintaining the rats and supporting their growth. Whole adrenal cortex extracts which contain 17-hydroxy-11-dehydrocorticosterone and similar steroids can therefore be assayed for their complete cortical hormone activity by the method as previously described (Am. J. Phys. 117: 678 1936).