Mouse skin bioassay of smoke condensates from cigarettes containing different levels of cocoa

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Abstract
Smoke condensates derived from three cigarette types of identical blend to which 0, 1 and 3% cocoa powder was added to the filler were assayed on mice by chronic dermal application (skin painting). For each cigarette type, three condensate doses were applied: 60, 90 and 125 mg dry condensate/mouse/week. The results obtained in this study do not provide evidence that the biological activity of the condensates, as indicated by the occurrence of non‐tumorous and tumorous lesions, is enhanced by the addition of cocoa.