Viruria in dogs after injection of coxsackie B-1 virus into a renal artery.

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Abstract
Injection of Coxsackie B-l virus into the right renal artery of anesthetized dogs resulted in virus detection in the urine if viremia greater than 102 50% tissue culture infective doses per ml was sustained. Virus appeared in ureteral urine from both kidneys, despite unilateral injections, as early as 30 seconds after virus infusion for approximately 1 minute. In experiments with free flow of urine, virus was always detected before or coincident with the appearance of simultaneously injected Hippuran-I131 or phenol red. In stop-flow studies, virus was first detected in specimens from the distal tubular area (or just proximal to it) as determined from sodium concentrations, but continued to appear in specimens from more proximal areas of the nephron. In three experiments virus was present in tubular urine but absent in glomerular urine marked by the excretion of ferro-cyanide. We conclude that facilitated excretion of Coxsackie B-l virus into urine in the area of the distal tubule occurred under the conditions of these experiments.