Solubility of Methoxyflurane in Rubber

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Abstract
The Ostwald partition coefficient for methoxyflurane in rubber was found to be 742 at 25 [degree]C. Uptake by the rubber components of an anesthetic system significantly retarded the rise of methoxyflurane concentration within it. The release of methoxyflurane from saturated rubber components retarded the fall of methoxyflurane concentration in the circle during washout. (These effects were greatest at low flow rates.) In clinical use, these factors contribute to slow induction and emergence. Release of methoxyflurane may significantly affect a subsequent anesthetic for which the same rubber goods are used.

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