Biosynthetic pathway of 2-deoxystreptamine.

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Abstract
Four 2-deoxystreptamine (DOS) related compounds including S-11-P, isolated as an intermediate of DOS biosynthesis, were supplemented to the culture of a DOS- mutant of Bacillus circulans. Among the tested aminocyclitol compounds, S-11-P alone was converted to DOS. Addition of other aminocyclitols neither produced antibiotic nor inhibited the incorporation of S-11-P and DOS into butirosins. By these facts, S-11-P was confirmed clearly to be an intermediate of DOS biosynthesis.