Cell cytotoxicity due to specific influenza antibody production in vitro after recent influenza antigen stimulation.

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Abstract
[Human] peripheral blood leukocytes obtained after vaccination or natural illness with influenza were assayed for cytotoxicity against influenza virus-infected cells. Approximately 7 days after vaccination or the onset of respiratory illness, peak cytotoxicity was demonstrated in a Cr-release assay. Secretion of specific antibody [Ab] against hemagglutinin from the leukocytes during in vitro incubation was demonstrated in quantities that would mediate the cell cytotoxicity observed. Ab secretion was inhibited by exposure to cycloheximide but not by exposure to trypsin. The secretion of Ab against hemagglutinin from peripheral blood leukocytes occurred only at the time of maximal cytotoxicity. Secretion of specific Ab was demonstrated in vitro after recent viral antigen stimulation. This Ab is capable of conveying cytotoxic capacity to peripheral blood leukocytes that may be important in the recovery process from acute viral infection.