Renal Tubular Function During Severe Metabolic Acidosis

Publisher Website
Google Scholar
Abstract
Acute severe metabolic acidosis was produced in well-hydrated dogs by rapid infusion of HC1. With reductions in mean blood pH to 7.01 [plus or minus] .07 and in mean CO2 content to 5.8 [plus or minus] 1.2 meq./l. maximal tubular secretion of p-aminohippurate was reduced by an average of 44%, but there was no change in the maximal rate of glucose reabsorption. The protein binding of PAH in oxylated plasma, as measured by a cellophane dialysis technique, is the same at pH 7.3 and pH 6.5.

This publication has 9 references indexed in Scilit: