Molecular characterization of 15 rearrangements among 90 human in vivo somatic mutants shows that deletions predominate.
Open Access
- 1 February 1987
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 7 (2) , 956-960
- https://doi.org/10.1128/mcb.7.2.956
Abstract
Ninety hypoxanthine phosphoribosyltransferase-deficient mutants were isolated from lymphocytes of 31 individuals drawn from both control populations and populations exposed to low doses of ionizing radiation. Southern analysis of the DNA revealed altered hybridization patterns in 15 mutants. Of these, 14 changes consisted of deletions of 2 to 40 kilobases or more.This publication has 18 references indexed in Scilit:
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