The Cellular Basis of Hepatic Fibrosis -- Mechanisms and Treatment Strategies

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Abstract
Hepatic fibrosis is a common response to chronic liver injury from many causes, including alcohol, persistent viral and helminthic infections, and hereditary metal overload. Emerging evidence suggests that cellular mechanisms of hepatic fibrosis are shared among these different insults and, moreover, that the liver's response is a paradigm for parenchymal wound healing in other tissues.Advances in the isolation and characterization of liver cells, in conjunction with progress in matrix and cytokine biology, have led to important new insights about the cellular basis of hepatic fibrosis. In particular, the hepatic lipocyte (also known as the stellate, fat-storing, perisinusoidal, or Ito . . .