Production of Renal Hypertension in Adrenalectomized Dogs on Constant Hormone Replacement Therapy

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Abstract
This study assessed the importance of increased aldosterone secretion secondary to acute activation of the renin-angiotensin system for development of chronic 1 kidney renal hypertension. In dogs with intact adrenals, reduction of renal blood flow by 55-60% promptly produced mild chronic hypertension. The onset of hypertension was associated with transient Na retention and hyperreninemia, but plasma volume did not change. Although mineralocorticoid hypersecretion was impossible in adrenalectomized dogs maintained with constant steroid therapy, hypertension was still successfully produced. In contrast to the dogs with intact adrenals, hypertension in the adrenalectomized group was characterized by chronically increased plasma renin activity and plasma volume. Hypersecretion of mineralocorticoid hormones during the early high renin phase is not essential for production of chronic 1 kidney renal hypertension.