Antihypertensive Effect of Spironolactone (SC-9420) on Experimental Renal Hypertension

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Abstract
Spironolactone was administered to rabbits with experimental renal hypertension. The blood pressure of these rabbits was decreased during spironolactone therapy, A marked increase in Na and H2O excretion was noted on the 3rd day, but K excretion did not change at that time. Treatment with spironolactone caused a rise of serum potassium in hypertensive rabbits. It is probable that spironolactone moves intracellular potassium out to extracellular space. It is assumed from these results that water and electrolyte metabolism is not normal in experimental renal hypertension, probably accompanied by excessive mineralocorticoid secretion. But the abnormal water and electrolyte metabolism, and hyperaldosteronism in experimental renal hypertension seem to play an independent different role in the development and maintenance of arterial hypertension.

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