THE INFLUENCE OF STEROIDS ON THE RESTORATION OF HYPERTENSION IN HYPOPHYSECTOMIZED RATS

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Abstract
Following the establishment of exptl. renal hypertension in rats, hypophysectomy or adrenalectomy causes a fall of blood pressure which may in some cases reach levels below normal. The hypertension may then be partially, though rarely completely restored by the admn. of desoxy-corticosterone or adrenal cortical extracts. Progesterone, testosterone, or estradiol have no blood pressure raising properties in these animals. Testosterone and estradiol exhibit toxic or lethal effects following hypophysectomy. Either larger amts. of desoxycorticosterone or adrenal cortical extract are required for the maintenance of hypertension than for life or for normal electrolyte balance, or there is an additional unknown factor from the adrenal cortex which is concerned with the maintenance of blood pressure.