THE ACTION OF HISTAMINE ON THE BRONCHIOLES AND PULMONARY VESSELS OF THE GUINEA PIG

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Abstract
The experiments cited show that the 2 effects[long dash]pulmonary vasoconstriction and bronchoconstriction[long dash]are not readily separated except in the case of very small doses of histamine, with which it is possible to get a rise in pulmonary pressure without evidence of bronchoconstriction. Bronchoconstriction was obtained in guinea pigs with doses of histamine ranging from 0.000,10 mgm. to 0.011,70 mgm. per kgm. of body weight, 25 of the 33 animals studied responding to doses ranging from 0.000,10 mgm. to 0.002,63 mgm. per kgm. of body weight. Pulmonary vasoconstriction, without evidence of bronchoconstriction, was obtained with doses of histamine ranging from 0.000,093 to 0.003,1 mgm. per kgm. of body weight. In this same series of animals, bronchoconstriction was obtained, in addition, only with larger doses, ranging from 0.000,23 mgm. to 0.10 mgm. per kgm.

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