Evaluation of Suspected Dementia

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Abstract
In their review of the evaluation of dementia (Aug. 1 issue),1 Geldmacher and Whitehouse expressed their “opinion . . . that apolipoprotein E testing will not be ready for clinical use as either a predictive or a diagnostic test until better population-based estimates of risk and appropriate genetic counseling are available.” There is virtual unanimity regarding the lack of support for apolipoprotein E genotyping in the prediction of asymptomatic persons — whether or not they have relatives with Alzheimer's disease.2 No apolipoprotein E genotype predicts accurately whether or when Alzheimer's disease will develop. However, the rationale for using apolipoprotein E genotyping for diagnosis is quite different.2,3

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