DBcAMP effect on the expression of GFAP and of its encoding mRNA in astroglial primary cultures
- 1 January 1991
- Vol. 4 (3) , 322-326
- https://doi.org/10.1002/glia.440040310
Abstract
Short term and chronic dBcAMP effects on the expression of glial fibrillary acidic protein (GFAP) in astroglial primary cultures are investigated. Short (48 h) and long (more than 7 days) treatments with the cAMP derivative induce both cell shape changes and an increase in GFAP immunolabelling. Such effects are only associated with an increase in GFAP and in GFAP-mRNA levels in the long term treatment. These results suggest that the short term effect of dBcAMP induces post-translational modifications of the protein whereas the long term effect is associated with an increase in GFAP mRNA transcription and/or stability.Keywords
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